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Lactuxan (Lettuce bacterial spot)

Project funded by the Rhône-Alpes region and Europe (FEADER fund), 2016-2020.
Key words: Lettuce - Xanthomonas - Bacteriosis.
Lettuce bacterial spot causes significant economic losses for market gardeners in the Rhône-Alpes region every year. SERAIL, an association of professional market gardeners in the Rhône Alpes region, and our team have joined forces to tackle this regional problem, with an innovative approach to understanding and combating the disease.

EVA (Extracellular Vesicles of Agrobacterium)

Implication of extracellular vesicles in trophic competition in the bacterium Agrobacterium tumefaciens, 2021, Project Financed by the FR BioEEnViS (collaboration DTAMB, Centre Technologique de Microstructures).
Key words: Extracellular vesicles, Trophic resources, Hydroxycinnamic acid.
The production of extracellular vesicles (EVs) is a universally conserved process in all three domains of life. In bacteria, there are different types of extracellular vesicle, the main and most studied being the Outer membrane vesicle. In connection with our work on the perception and response of A. tumefaciens to certain compounds synthesized by the plant, such as hydroxycinnamic acids (HCAs) (Campillo et al. 2014; Meyer et al. 2018), we aim via this project to demonstrate that in A. tumefaciens, HCAs trigger increased synthesis of EVs, containing enzymes responsible for the degradation and utilization of HCAs as a trophic resource. The ability to degrade HCAs via VEs would give Agrobacterium an early competitive advantage in colonizing the plant environment.

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Role of extracellular vesicles in competition between rhizosphere bacteria, 2021-2022, EC2CO Project (Collaboration Equipe Emersys, UMR 1345 IRHS Institut de Recherche en Horticulture et Semences, INRAE).
Key words: Extracellular vesicles, Trophic resources.
The aim of this project is to characterize the involvement of extracellular vesicles produced by Agrobacterium in competition between rhizosphere bacteria and, more generally, the effect of these vesicles in structuring the rhizosphere microbiota using an integrative approach based on the A. tumefaciens model (from gene function and associated phenotypes to microbiota functioning).  This project will provide essential data for understanding the role of extracellular vesicles in microbial interactions in response to environmental signals.