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Bactéries Pathogènes Opportunistes et Environnement

Team Leaders : COURNOYER Benoit & SERGENTET Delphine


Permanent Members

BLAHA Didier Lecturer (MCF), UCB
BOIRON Patrick Professor (PR), UCB
COURNOYER Benoit Research Director (DR), CNRS
FRENEY Jean Professor (PR), UCB
RODRIGUEZ-NAVA Véronica Lecturer (MCF), UCB
THEVENOT SERGENTET Delphine Lecturer (MCF), VetAgroSup
BERGERON Emmanuelle Engineer (IE), UCB
COMMUN Carine Technician (T), UCB
MARJOLET Laurence Engineer (IE), VetAgroSup
GANET Sarah Engineer (IE), VetAgroSup
BOUVIER-CROZIER Marion Sarah Engineer (IE), VetAgroSup
MAZUY-CRUCHAUDET Christine Engineer (IE), VetAgroSup

Non permanent members

GLEIZAL Audrey Assistant Engineer CDD
RIBUN Sébastien Engineer (IE)
GALIA Wessam Post-doctoral researcher
MARTI Romain Post-doctoral researcher
MISZCZYCHA Stéphane Post-doctoral researcher
BOUKAREB Amine PhD Student (2012-2015)
KERANGART Stéphane PhD Student (2012-2015)
PAGES Laurence PhD Student (2012-2015)
BERNARDIN Claire PhD Student (2013-2016)
DOUELLOU Thomas PhD Student (2013-2016)
VOISIN Jérémy PhD Student (2013-2016)
RANNOU Emilie PhD Student (visiteur)

Research field and main goals

Our research activities are dedicated to the understanding of the ecology and evolution of opportunistic bacterial pathogens. The originality of our approaches is in part our ability at integrating social (urbanization, behavior) and environmental issues in the understanding of the factors and forces leading to opportunistic infections and epidemic outbreaks. The notions of invasiveness and expology are investigated, with a particular emphasis on the impact of the biotopes (physico-chemical components, structure, etc) and related biocenosis on the fate of bacterial opportunistic pathogens (BOP) and their virulence. The incidences of environmental filters including agricultural (food, crops, etc) and urban practices (wastewater treatments, management of urban waters) on the dissemination of BOP and their ability at colonizing certain individuals (e. g. people with cystic fibrosis, children and seniors) are investigated. These studies are done without a priori on the BOP species likely to be encountered in the investigated outdoor contexts. However, the most significant populations representing human health hazards among these sites tend to belong to proteobacteria such as Pseudomonas aeruginosa, Burkholderia of the cepacia complex (Bcc), Stenotrophomonas maltophilia, E. coli shiga-toxin producers, and Actinobacteria such as Nocardia. These bacteria are responsible for community-acquired infections, and some, are well-known etiological agents of nosocomial infections.
Fig. 6.1 shows an organizational chart of our research activities. The team’s research activities are divided into four themes: (i) Bio-geography and matrices (sources, transfers, dynamics), (ii) Population diversity and structure (phenotype, genotype, genome), (iii) Expology (exposure, colonization), and (iv) Genetic adaptations towards environmental constraints (virulence, outdoor functions).

Fig. 6.1: Main research areas of the BPOE team. 1, 2 and 6 indicate our contributions in the understanding of the incidences of various outdoor contexts on BOP prevalence and dissemination. 3 indicates our contributions in the understanding of properties (metabolic activities, adherence, etc) explaining the success of some BOP genotypes in particular outdoor contexts. 4 concerns the expology issues including the investigations of factors that can contribute at exacerbating/reducing BOP virulence among matrices exposing human populations to these organisms. 5 concerns our research activities on clinical cases including the incidence of a human colonization on the selection or loss of particular genetic/genomic elements among BOP.

Bibliography :


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  • Jameh, N., Galia, W., Awussi, A. A., Roux, E., Genay, M., Perrin, C., & Dary-Mourot, A. (2016). Characterization of a new peptide transport system in Streptococcus thermophilus. Food Research International, 86, 34-45. doi:10.1016/j.foodres.2016.04.039

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