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En - Multi-résistance Environnementale et Efflux Bactérien

Team Leader : NAZARET Sylvie
Team Coleader : DIJOUX-FRANCA Marie-Geneviève

Team :

Permanent members

BROTHIER Elisabeth Engineer (IE), CNRS
DIJOUX-FRANCA Marie-Geneviève Professor (PR), UCB
FAVRE-BONTE Sabine Lecturer (MCF), UCB
MEIFFREN Guillaume Engineer (IE), UCB
MICHALET Serge Lecturer (MCF), ISPB
NAZARET Sylvie Research Scientist (CR), CNRS
BODILIS Josselin Lecturer (MCF), UCB(visite)

Non permanent members

Pham Nam Hoang PhD Student USTH
Samira Ait Moussa PhD Student 12-15
Moussa Aoudalkarim PhD Student 12-15
Salomon Bouba PhD Student 13-16
Elodie Denet PhD Student 14-17
Cassandra Backes Master Student 14-15
Pauline Feuillet Master Student 14-15

in progress...



Bibliography :


  • Bodilis, J., Denet, E., Brothier, E., Graindorge, A., Favre-Bonté, S., Nazaret, S., 2018. Comparative Genomics of Environmental and Clinical Burkholderia cenocepacia Strains Closely Related to the Highly Transmissible Epidemic ET12 Lineage. Frontiers in Microbiology 9.

  • Denet, E., Vasselon, V., Burdin, B., Nazaret, S., Favre-Bonté, S., 2018. Survival and growth of Stenotrophomonas maltophilia in free-living amoebae (FLA) and bacterial virulence properties. PLOS ONE 13, e0192308.

  • Radix, S., Jordheim, A.D., Rocheblave, L., N'Digo, S., Prignon, A.-L., Commun, C., Michalet, S., Dijoux-Franca, M.-G., Mularoni, A., Walchshofer, N., 2018. N,N′ -disubstituted cinnamamide derivatives potentiate ciprofloxacin activity against overexpressing NorA efflux pump Staphylococcus aureus 1199B strains. European Journal of Medicinal Chemistry.

  • Rouifed, S., Puijalon, S., Bardon, C., Meiffren, G., Buonomo, A., Sebei, N., Poussineau, S., Vallier, F., Shimoda, M., Piola, F., 2018. Comparison of defence and performance traits between one widespread clone and native populations in a major invasive plant species. Diversity and Distributions.


  • Anne-Emmanuelle, H., Hasna, B., Antoine, B., Marjolaine, R., Guillaume, M., Laetitia, C.-G., Gilles, C., Aude, H.-B., 2017. Control of Endophytic Frankia Sporulation by Alnus Nodule Metabolites. Molecular Plant-Microbe Interactions 30, 205–214.

  • Bardon, C., Poly, F., Haichar, F.Z., Le Roux, X., Simon, L., Meiffren, G., Comte, G., Rouifed, S., Piola, F., 2017. Biological denitrification inhibition (BDI) with procyanidins induces modification of root traits, growth and N status in Fallopia x bohemica. Soil Biology and Biochemistry 107, 41-49.

  • Crampon, M., Cébron, A., Portet-Koltalo, F., Uroz, S., Le Derf, F., Bodilis, J., 2017. Low effect of phenanthrene bioaccessibility on its biodegradation in diffusely contaminated soil. Environmental Pollution 225, 663-673.

  • Denet, E., Coupat-Goutaland, B., Nazaret, S., Pélandakis, M., Favre-Bonté, S., 2017. Diversity of free-living amoebae in soils and their associated human opportunistic bacteria. Parasitology Research.

  • El Moujahid, L., Le Roux, X., Michalet, S., Bellvert, F., Weigelt, A., Poly, F., 2017. Effect of plant diversity on the diversity of soil organic compounds. PLOS ONE 12, e0170494.

  • Guyonnet, J.P., Vautrin, F., Meiffren, G., Labois, C., Cantarel, A.A.M., Michalet, S., Comte, G., Haichar, F.Z., 2017. The effects of plant nutritional strategy on soil microbial denitrification activity through rhizosphere primary metabolites. FEMS Microbiology Ecology 93.

  • Hay, A.E., Boubakri, H., Buonomo, A., Rey, M., Meiffren, G., Cotin-Galvan, L., Comte, G., Herrera-Belaroussi, A., 2017. Control of Endophytic Frankia Sporulation by Alnus Nodule Metabolites. Molecular Plant-Microbe Interactions 30, 205-214.

  • Lebot, V., Lawac, F., Michalet, S., Legendre, L., 2017. Characterization of taro [Colocasia esculenta (L.) Schott] germplasm for improved flavonoid composition and content. Plant Genetic Resources 15, 260-268.

  • Lhuissier, T., Mercier, P.-E., Michalet, S., Lebot, V., Legendre, L., 2017. Colorimetric assessment of kava (Piper methysticum Forst.) quality. Journal of Food Composition and Analysis 59, 27-34.

  • Michalet, S., Rouifed, S., Pellassa-Simon, T., Fusade-Boyer, M., Meiffren, G., Nazaret, S., Piola, F., 2017. Tolerance of Japanese knotweed s.l. to soil artificial polymetallic pollution: early metabolic responses and performance during vegetative multiplication. Environmental Science and Pollution Research 1-11.

  • Pham, H.N., Michalet, S., Bodillis, J., Nguyen, T.D., Nguyen, T.K.O., Le, T.P.Q., Haddad, M., Nazaret, S., Dijoux-Franca, M.-G., 2017. Impact of metal stress on the production of secondary metabolites in Pteris vittata L. and associated rhizosphere bacterial communities. Environmental Science and Pollution Research 1-16.


  • Bardon, C., Poly, F., Piola, F., Pancton, M., Comte, G., Meiffren, G., Haichar, F.Z., 2016. Mechanism of biological denitrification inhibition (BDI): procyanidins induce an allosteric transition of the membrane-bound NO3-reductase through membrane alteration. FEMS Microbiology Ecology 92, fiw034.

  • Bodilis, J., Youenou, B., Briolay, J., Brothier, E., Favre-Bonté, S., Nazaret, S., 2016. Draft Genome Sequences of Stenotrophomonas maltophilia Strains Sm32COP, Sm41DVV, Sm46PAILV, SmF3, SmF22, SmSOFb1, and SmCVFa1, Isolated from Different Manures in France. Genome Announcements 4, e00841-16.

  • Cavé, L., Brothier, E., Abrouk, D., Bouda, P.S., Hien, E., Nazaret, S., 2016. Efficiency and sensitivity of the digital droplet PCR for the quantification of antibiotic resistance genes in soils and organic residues. Applied Microbiology and Biotechnology 1-12.

  • Chaabane, F., Mustapha, N., Mokdad-Bzeouich, I., Sassi, A., Kilani-Jaziri, S., Dijoux Franca, M.G., Michalet, S., Fathallah, M., Krifa, M., Ghedira, K., Chekir-Ghedira, L., 2016. In vitro and in vivo anti-melanoma effects of Daphne gnidium aqueous extract via activation of the immune system. Tumor Biology 37, 6511-6517.

  • Deredjian, A., Alliot, N., Blanchard, L., Brothier, E., Amane, M., Cambier, P., Jolivet, C., Khelil, M.N., Nazaret, S., Saby, N., Thioulouse, J., Favre-Bonté, S., 2016. Occurrence of Stenotrophomonas maltophilia in agricultural soils and antibiotic resistance properties. Research in Microbiology.

  • Lebot, V., Michalet, S., Legendre, L., 2016. Identification and quantification of phenolic compounds responsible for the antioxidant activity of sweet potatoes with different flesh colours using high performance thin layer chromatography (HPTLC). Journal of Food Composition and Analysis 49, 94-101.

  • Muñoz-Cuervo, I., Malapa, R., Michalet, S., Lebot, V., Legendre, L., 2016. Secondary metabolite diversity in taro, Colocasia esculenta (L.) Schott, corms. Journal of Food Composition and Analysis 52, 24-32.

  • Randriamboavonjy, J.I., Loirand, G., Vaillant, N., Lauzier, B., Derbré, S., Michalet, S., Pacaud, P., Tesse, A., 2016. Cardiac Protective Effects of Moringa oleifera Seeds in Spontaneous Hypertensive Rats. American Journal of Hypertension 29, 873-881.

  • Youenou, B., Hien, E., Deredjian, A., Brothier, E., Favre-Bonté, S., Nazaret, S., 2016. Impact of untreated urban waste on the prevalence and antibiotic resistance profiles of human opportunistic pathogens in agricultural soils from Burkina Faso. Environmental Science and Pollution Research 1-13.


  • Chahad, A.M., Michalet, S., Bechir, A.B., Tidjani, A., Nkongmeneck, B.A., Dijoux-Franca, M.-G., 2015. Medicinal Plants from the Ouaddaï Province (Chad): An Ethnobotanical Survey of Plants Used in Traditional Medicine. The Journal of Alternative and Complementary Medicine 21, 569-577.

  • Christina, M., Rouifed, S., Puijalon, S., Vallier, F., Meiffren, G., Bellvert, F., Piola, F., 2015. Allelopathic effect of a native species on a major plant invader in Europe. The Science of Nature 102, 1-8.

  • Yan, X., Sivignon, A., Alcouffe, P., Burdin, B., Favre-Bonté, S., Bilyy, R., Barnich, N., Fleury, E., Ganachaud, F., Bernard, J., 2015. Brilliant glyconanocapsules for trapping of bacteria. Chem. Commun. 51, 13193-13196.

  • Youenou, B., Favre-Bonté, S., Bodilis, J., Brothier, E., Dubost, A., Muller, D., Nazaret, S., 2015. Comparative genomics of environmental and clinical <i>Stenotrophomonas maltophilia</i> strains with different antibiotic resistance profiles. Genome Biology and Evolution evv161.


  • Azzouzi, S., Zaabat, N., Medjroubi, K., Akkal, S., Benlabed, K., Smati, F., Dijoux-Franca, M.-G., 2014. Phytochemical and biological activities of <i>Bituminaria bituminosa L.</i> (Fabaceae). Asian Pacific Journal of Tropical Medicine 7, S481-S484.

  • Chaabane, F., Krifa, M., Matera, E., Loussaeif, A., Dijoux-Franca, M.-G., Ghedira, K., Dumontet, C., Chekir-Ghedira, L., 2014. In vitro antileukaemic activity of extracts from Daphne gnidium leaves against sensitive and multidrug resistant K562/R7 cells. Tumour Biology: The Journal of the International Society for Oncodevelopmental Biology and Medicine 35, 8991-8998.

  • Deredjian, A., Colinon, C., Hien, E., Brothier, E., Youenou, B., Cournoyer, B., Dequiedt, S., Hartmann, A., Jolivet, C., Houot, S., Ranjard, L., Saby, N.P.A., Nazaret, S., 2014. Low occurrence of Pseudomonas aeruginosa in agricultural soils with and without organic amendment. Frontiers in Cellular and Infection Microbiology 4.

  • Kilani-Jaziri, S., Ghedira, Z., Nars, N., Krifa, M., Ghedira, K., Dijoux-Franca, M.G., Ghedira Chekir, L., 2014. Evaluation of in vitro antioxidant and apoptotic activities of Cyperus rotundus. Asian Pacific Journal of Tropical Medicine 7, 105-112.

  • Lavenir, R., Petit, S.M.-C., Alliot, N., Ribun, S., Loiseau, L., Marjolet, L., Briolay, J., Nazaret, S., Cournoyer, B., 2014. Structure and fate of a Pseudomonas aeruginosa population originating from a combined sewer and colonizing a wastewater treatment lagoon. Environmental Science and Pollution Research 21, 5402-5418.

  • Nazaret, S., Aminov, R., 2014. Role and prevalence of antibiosis and the related resistance genes in the environment. Frontiers in Microbiology 5.

  • Toussirot, M., Nowik, W., Hnawia, E., Lebouvier, N., Hay, A.-E., de la Sayette, A., Dijoux-Franca, M.-G., Cardon, D., Nour, M., 2014. Dyeing properties, coloring compounds and antioxidant activity of Hubera nitidissima (Dunal) Chaowasku (Annonaceae). Dyes and Pigments 102, 278-284.

  • Youenou, B., 2014. Les sols anthropisés, incubateurs d'agents bactériens pathogènes de l'homme : typage génétique, métabolique et antibio-résistance d'agents opportunistes.

  • Youenou, B., Brothier, E., Nazaret, S., 2014. Diversity among strains of Pseudomonas aeruginosa from manure and soil, evaluated by multiple locus variable number tandem repeat analysis and antibiotic resistance profiles. Research in Microbiology 165, 2-13.